*Eddie Darko(Holmes Osborne)-Donnie Darko's father who is very relaxed in his way of life
*Rose Darko(Mary McDonnell)-Donnie Darko's mother who does her best to cope with her schizophrenic son
*Frank(James Duvall)- Giant bunny from a tangent universe that acts as Donnie's guide throughout the movie
*Jim Cunningham(Patrick Swayze)- Motivational speaker known for his trademarked "Love and Fear" theory
*Karen Pomeroy(Drew Barrymore)-Donnie Darko's English teacher who uses a very original method of teaching
*Gretchen Ross(Jena Malone)- New girl in school and Donnie's girlfriend
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